loading...| Preferred Name |
dimercaprol |
| Synonyms |
alpha,beta-dithioglycerol 2,3-dithiopropanol dimercaptopropanol BAL 3-hydroxy-1,2-propanedithiol dithioglycerine 1,2-dimercapto-3-propanol British anti-Lewisite dimercaprolum dithioglycerol British antilewisite 2,3-dimercaptol-1-propanol 2,3-disulfanylpropan-1-ol 2,3-mercaptopropan-1-ol 1,2-dithioglycerol British anti-lewisite 2,3-Mercaptopropanol 2,3-dimercaptopropanol dimercaprol 2,3-dimercapto-1-propanol 2,3-Dimercapto-1-propanol sulfactin |
| Definitions |
A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury. |
| ID |
http://purl.obolibrary.org/obo/CHEBI_64198 |
| charge |
0 |
| database_cross_reference |
PMID:12605205 DrugBank:DB06782 PMID:14882450 PMID:21006485 KEGG:D00167 Wikipedia:Dimercaprol PMID:21803782 CAS:59-52-9 Drug_Central:3150 Patent:US2402665 PMID:9292286 KEGG:C02924 Reaxys:1732058 |
| definition |
A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury. |
| formula |
C3H8OS2 |
| has role | |
| has_exact_synonym |
2,3-disulfanylpropan-1-ol |
| has_obo_namespace |
chebi_ontology |
| has_related_synonym |
alpha,beta-dithioglycerol 2,3-dithiopropanol dimercaptopropanol BAL 3-hydroxy-1,2-propanedithiol dithioglycerine 1,2-dimercapto-3-propanol British anti-Lewisite dimercaprolum dithioglycerol British antilewisite 2,3-dimercaptol-1-propanol 2,3-mercaptopropan-1-ol 1,2-dithioglycerol British anti-lewisite 2,3-Mercaptopropanol 2,3-dimercaptopropanol dimercaprol 2,3-dimercapto-1-propanol 2,3-Dimercapto-1-propanol sulfactin |
| id |
CHEBI:64198 |
| in_subset | |
| inchi |
InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2 |
| inchikey |
WQABCVAJNWAXTE-UHFFFAOYSA-N |
| label |
dimercaprol |
| mass |
124.22500 |
| monoisotopicmass |
124.00166 |
| notation |
CHEBI:64198 |
| prefLabel |
dimercaprol |
| smiles |
OCC(S)CS |
| treeView | |
| subClassOf |