loading...| Preferred Name |
Cadherin-5 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21021 |
| code |
C21021 |
| DEFINITION |
Cadherin-5 (784 aa, ~88 kDa) is encoded by the human CDH5 gene. This protein is involved in endothelial cell polarity and cell-cell adhesion. |
| DesignNote |
Encoded by human CDH5 Gene (CDH Family), 784-amino acid 87.5 kD (precursor) Vascular Endothelial Cadherin is a Ca(2+)-dependent homophilic endothelial cell-cell adhesion type I membrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Expressed specifically in endothelial cells and brain, VE-Cadherin is found mainly at cell-cell boundaries, associated with intercellular junctions. CDH5 may play a role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton. |
| FULL_SYN |
Vascular Endothelial Cadherin Vascular Endothelial Cadherin 1 Cadherin 5 Cadherin-5 CD144 Antigen 7B4 Antigen VE-Cadherin CDH5 Endothelial-Specific Cadherin |
| label |
Cadherin-5 |
| Legacy Concept Name |
VE-Cadherin |
| OMIM_Number |
601120 |
| Preferred_Name |
Cadherin-5 |
| prefixIRI |
Thesaurus:C21021 |
| prefLabel |
Cadherin-5 |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P33151 |
| UMLS_CUI |
C1741231 |
| subClassOf |