loading...| Preferred Name |
TNF Receptor Family Protein |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19285 |
| code |
C19285 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection. They are cell-surface proteins that interact with a corresponding TNF-related ligand family. The receptors share homology in the extracellular domain, which contains 3 to 6 cysteine-rich pseudorepeats, but are generally not related in their cytoplasmic regions. However, the intracellular domains (ICDs) of TNFR family members TNFR1 and FAS/APO1/CD95, which can activate apoptotic cell death, do have a region of homology in an oligomerization interface known as the death domain. (from OMIM 603366) |
| Display_Name |
TNF Receptor Family Protein |
| FULL_SYN |
TNFR TNF Receptor Tumor Necrosis Factor Receptor Superfamily Tumor Necrosis Factor Receptor Family Tumor Necrosis Factor Receptor TNF Receptor Superfamily TNFRSF Protein TNF Receptor Family Protein |
| label |
TNF Receptor Family Protein |
| Legacy Concept Name |
TNF_Receptor_Family_Protein |
| Preferred_Name |
TNF Receptor Family Protein |
| prefixIRI |
Thesaurus:C19285 |
| prefLabel |
TNF Receptor Family Protein |
| Semantic_Type |
Receptor Amino Acid, Peptide, or Protein |
| UMLS_CUI |
C0077503 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||