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loading...| Preferred Name |
Topoisomerase-I Inhibitor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1904 |
| CHEBI_ID |
CHEBI:50276 |
| code |
C1904 |
| Concept_In_Subset | |
| Contributing_Source |
CTRP |
| DEFINITION |
Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis. |
| Display_Name |
Topoisomerase-I Inhibitor |
| FULL_SYN |
Topoisomerase-I Inhibitors Topoisomerase-I Inhibitor |
| label |
Topoisomerase-I Inhibitor |
| Legacy Concept Name |
Topoisomerase-I_Inhibitor |
| Preferred_Name |
Topoisomerase-I Inhibitor |
| prefixIRI |
Thesaurus:C1904 |
| prefLabel |
Topoisomerase-I Inhibitor |
| Semantic_Type |
Chemical Viewed Functionally |
| UMLS_CUI |
C0594374 |
| subClassOf |
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