loading...| Preferred Name |
Topoisomerase Inhibitor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1748 |
| ALT_DEFINITION |
A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer. |
| code |
C1748 |
| DEFINITION |
Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis. |
| FULL_SYN |
Topoisomerase Inhibitors Topoisomerase Inhibitor DNA Topoisomerase Inhibitors topoisomerase inhibitor |
| label |
Topoisomerase Inhibitor |
| Legacy Concept Name |
Topoisomerase_Inhibitor |
| Preferred_Name |
Topoisomerase Inhibitor |
| prefixIRI |
Thesaurus:C1748 |
| prefLabel |
Topoisomerase Inhibitor |
| Semantic_Type |
Chemical Viewed Functionally |
| UMLS_CUI |
C0598317 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/CHEBI_70727 | Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体 | LOOM | |
| http://purl.obolibrary.org/obo/CHEBI_70727 | The Drug Ontology / 药物本体 | LOOM |