loading...| Preferred Name |
Cathepsin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16389 |
| ALT_DEFINITION |
Antigen(s) of the lysosomal proteinase or endopeptidase family and are encoded by the CTS gene. They can be considered as autoantigens and are commonly associated with systemic vasculitis, inflammatory rheumatic diseases, autoimmune hepatitis, and chronic inflammatory bowel diseases. |
| code |
C16389 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
| Contributing_Source |
CDISC CTRP |
| DEFINITION |
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis. |
| Display_Name |
Cathepsin |
| FULL_SYN |
Cathepsins CATHEPSIN Cathepsin |
| label |
Cathepsin |
| Legacy Concept Name |
Cathepsin |
| Preferred_Name |
Cathepsin |
| prefixIRI |
Thesaurus:C16389 |
| prefLabel |
Cathepsin |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| UMLS_CUI |
C0007428 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||