loading...| Preferred Name |
Fluorine F 18-Active Site Inhibited Factor VIIa |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157486 |
| code |
C157486 |
| Concept_In_Subset | |
| DEFINITION |
A radioconjugate containing a tissue factor (TF) tracer, a derivative of activated factor VII (FVIIa), labeled with fluorine F 18, with potential use for TF-expressing tumor imaging using positron emission tomography (PET). Upon administration of fluorine F 18 active site inhibited factor VIIa (18F-ASIS), the active site inhibited factor VIIa (FVIIai) moiety selectively targets and binds, with a much higher binding affinity than FVIIa, to TF. Upon PET imaging, tumor cells expressing TF can be visualized and assessed. TF, a transmembrane glycoprotein, is overexpressed on certain tumor cell types and is correlated with tumor aggression and poor prognosis. |
| FULL_SYN |
18F-ASIS Fluorine F 18-Active Site Inhibited Factor VIIa |
| label |
Fluorine F 18-Active Site Inhibited Factor VIIa |
| NCI_Drug_Dictionary_ID |
796741 |
| NCI_META_CUI |
CL937078 |
| PDQ_Closed_Trial_Search_ID |
796741 |
| PDQ_Open_Trial_Search_ID |
796741 |
| Preferred_Name |
Fluorine F 18-Active Site Inhibited Factor VIIa |
| prefixIRI |
Thesaurus:C157486 |
| prefLabel |
Fluorine F 18-Active Site Inhibited Factor VIIa |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||