loading...| Preferred Name |
Pixantrone Dimaleate |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82398 |
| Accepted_Therapeutic_Use_For |
non-Hodgkin's lyphoma |
| ALT_DEFINITION |
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics. |
| CAS_Registry |
144675-97-8 |
| Chemical_Formula |
C17H19N5O2.2C4H4O4 |
| code |
C82398 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. |
| Display_Name |
Pixantrone Dimaleate |
| FDA_UNII_Code |
P0R64C4CR9 |
| FULL_SYN |
Pixantrone Maleate BBR 2778 Pixantrone Dimaleate PIXANTRONE DIMALEATE Benz(g)isoquinoline-5,10-dione, 6,9-bis((2-aminoethyl)amino)-, (2Z)-2-butenedioate (1:2) Benz(g)Isoquinoline-5,10-Dione, 6,9-Bis((2-Aminoethyl)Amino)-, (2z)-2-Butenedioate (1:2) Pixuvri 6,9-Bis((2-Aminoethyl)Amino)Benzo(g)Isoquinoline-5,10-Dione (2z)-But-2-Enedioate (1:2) |
| Has_Free_Acid_Or_Base_Form | |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Pixantrone Dimaleate |
| Legacy Concept Name |
Pixantrone_Dimaleate |
| Maps_To |
Pixantrone Dimaleate |
| NCI_Drug_Dictionary_ID |
269678 |
| NCI_META_CUI |
CL408667 |
| PDQ_Closed_Trial_Search_ID |
269678 |
| PDQ_Open_Trial_Search_ID |
269678 |
| Preferred_Name |
Pixantrone Dimaleate |
| prefixIRI |
Thesaurus:C82398 |
| prefLabel |
Pixantrone Dimaleate |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||