loading...| Preferred Name |
DNA Repair |
| Synonyms |
Repairs, Base Excision |
| Definitions |
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light. |
| ID |
http://purl.bioontology.org/ontology/MESH/D004260 |
| altLabel |
Repairs, Base Excision Excision Repair Repair, Excision Nucleotide Excision Repair Nucleotide Excision Repairs Excision Repair, Nucleotide Base Excision Repair Base Excision Repairs Excision Repair, Base Repair, Base Excision Excision Repairs |
| AN |
coord IM with specific DNA (IM) |
| AQL |
DE GE IM PH RE |
| cui |
C0524550 C1158530 C0012899 C0015249 |
| DC |
1 |
| definition |
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light. |
| DX |
19740101 |
| FX |
D011740 |
| HN |
74(71) |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000235 |
| Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D011740 http://purl.bioontology.org/ontology/MESH/D043382 |
| Machine permutation |
74 |
| Mapped from | |
| MDA |
19990101 |
| MMR |
20160617 |
| MN |
G05.219 G02.111.222 |
| notation |
D004260 |
| prefLabel |
DNA Repair |
| TERMUI |
T012952 T012950 T012951 T539783 |
| TH |
NLM (1998) NLM (2004) NLM (1991) NLM (1971) |
| tui |
T045 |
| subClassOf |