loading...| Preferred Name |
rhodopsin-like G-protein coupled receptor |
| Synonyms |
fam:rhodopsin class 1 G-protein coupled receptor class A G-protein coupled receptor |
| Definitions |
Category=family. Classification based on GRAFS system. [PMID:12761335] A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions. |
| ID |
http://purl.obolibrary.org/obo/PR_000001094 |
| comment |
Category=family. Classification based on GRAFS system. [PMID:12761335] |
| database_cross_reference |
IUPHAR:GPCRListForward?class=A PIRSF:PIRSF800006 |
| has exact synonym |
fam:rhodopsin class 1 G-protein coupled receptor class A G-protein coupled receptor |
| has_obo_namespace |
protein |
| id |
PR:000001094 |
| imported from | |
| label |
rhodopsin-like G-protein coupled receptor |
| notation |
PR:000001094 |
| prefLabel |
rhodopsin-like G-protein coupled receptor |
| textual definition |
A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions. |
| subClassOf |